It is defined as the dangerously high body temperature, rigid muscle and fast heart rate in response to certain drugs like drugs used in anesthesia. It can be a fatal condition if not treated urgently.
Following are the signs and symptoms of malignant hyperthermia:
The cause of malignant hyperthermia is genetic defect in the certain genes which increase the risk of hyperthermia when exposure to certain medicine which trigger this condition. RYR1 is the most common gene affected in malignant hyperthermia.
If left untreated following complications can occur:
- Bleeding problems
- Kidney failure
- Muscles breakdown
- Problems in clotting
The diagnosis of malignant hyperthermia is done by checking signs and symptoms during and after anesthesia. Genetic testing and muscle biopsy may help to find the actual cause of malignant hyperthermia.
Following options of treatment for malignant hyperthermia available:
- Extra fluids
- Medications like dantrolene
- Body cooling through ice packs and cool mist
- Supportive care